Dr. Walter E. Goldstein is the Coordinator of the Biotechnology Center, Shadow Lane Campus, University of Nevada Las Vegas as well as the President of Goldstein Consulting Company. He is an executive with 40 years of experience developing technology, products, and business. He led a research and development organization of 140 persons (35 Ph.D.'s) at Bayer (Miles, Inc.), a leading firm in biotechnology, clinical diagnostics, therapeutics, food ingredients, materials, chemicals, and consumer products. He led 35 persons (10 Ph.D.'s) at ESCAgenetics Corporation, which was a leading developer of plant-based technology for food, food ingredients and pharmaceuticals. He designed and developed cryogenic processes and equipment for Union Carbide Corporation. As Coordinator of the Biotechnology Center of UNLV, Dr. Walter E. Goldstein develops new business in training, laboratory service, and guiding entrepreneurial businesses that are interested in establishing enterprises in the Las Vegas Valley. Specific programs offered and in development in include forensic DNA profiling, assistance in training professionals for cross examination, microbiological identification and profiling, food safety, genetic basis for biotechnology improvements, and prevention of nosocomial infections.

He has transferred technology and lectured on engineering and science throughout the world. He is listed in American Men of Science and Who's Who. He organizes local publicity and program manages select events for the Silicon Valley Society of Competitive Intelligence Professionals. As Chair of the Northern California Pharmaceutical Discussion Group, he organized monthly events involving 100+ attendees while doubling the organization's cash position.

He is a Registered Professional Engineer and taught in the graduate school at the University of Notre Dame. Dr. Goldstein received his BS degree in chemical engineering from the Illinois Institute of Technology and his MS and Ph.D. degrees in chemical engineering from the University of Notre Dame. He holds an MBA from Michigan State University. He has 23 publications to his credit. Recently, he co-authored books entitled Technology Transfer of Plant Biotechnology, and Plant Cell and Tissue Culture for the Production of Food Ingredients.

He solved critical problems and developed important prototypes of Miles' diagnostic devices, directed the development of their fermentation products, and guided establishment of their molecular biology program and therapeutic protein development. He led development of immobilized cell processes and provided guidance and leadership for Miles' flavor and food ingredients businesses. Dr. Goldstein led a team to solve a critical impurity problem in a Miles extraction process. He introduced pilot plant computer technology for fermentation control at Miles. His leadership in quickly correcting process/product malfunctions saved Miles many millions of dollars on different occasions. He led numerous worldwide start-ups.

He is recognized for his contributions to developing ESCAgenetics plant cell tissue culture technology and for leading efforts on vanilla flavor and the anti-cancer therapeutic Taxol. He guided critical crop harvests where an error in timing would have meant loss of an expensive product, and he rebuilt their plant genetics programs. His leadership resulted in the assembly of intellectual property in cell culture. His leadership in coaching the tissue culture date palm program resulted in a line of plants for shipment to ex-U.S. locales. He identified collaborators and personnel at critical times for the company's genetics and flavor programs.

In his consulting practice, Dr. Goldstein has applied his modeling methods to structure business relationships and optimize economics. He has guided the planning and development of manufacturing for novel new processes to produce proteins. He has directly designed, specified, and organized installation of biotechnology facilities. His consulting activities and accomplishments include:

• Coordinator of the Biotechnology Center, Shadow Lane Campus, University of Nevada Las Vegas (2003-present), Developing Training, Laboratory Service, and Entrepreneur Assistance Programs in Forensic Science, Biomedical Fields, Food Safety, Nosocomial Infections, in the Genetic Basis of Biotechnology Developments, and in the proteomic basis of environmental biotechnology organisms of interest.
• Technical development of a plant-based process to manufacture proprietary proteins using a novel host
• Scaling up a fermentation manufacturing process involving complete retrofitting and build-out of a facility
• Co-inventor (issued patent) of a mammalian cell process to provide a natural blood product
• Devised a system/plan for manufacture of natural products from plants to serve health care and cosmetics industries that helped establish a public company
• Entrepreneurial development of a concept with potential application to treat Inflammable Bowel Syndrome
• Providing counsel and design input to companies developing plant cell culture technology
• Identifying collaborators for a technology, which can destroy microbes and avoid damage to proteins, and for an associated oxidation/reduction concept with potential impact on healthcare and industrial areas.
• Critical organizational impact and behavior modification to help a bioinformatics company launch its sales
• Completing a marketing evaluation for a contract service business in protein manufacturing
• Seeking biomedical applications for a non-invasive cardiac diagnosis system
• Finding applications for a unique data mining software system for business knowledge management
• Providing search consulting services in select areas
• Identifying parties interested in a novel method to isolate valuable compounds from soybean processes
• Inspecting pharmaceutical facilities to assure regulatory standards are met
• Analyzing solid oral pharmaceutical formulation to assess proprietary solubility, transport, and drug delivery characteristics

Industrial Background and Accomplishments
Goldstein Consulting Company, Foster City, CA (1994-Present)
Technology/business development & analysis, chemical engineering, biotechnology, process design, facility scale-up, process equipment and utility specification, procurement, marketing research

Applied to: fermentation, cell culture, dietary supplements, therapeutic proteins, small molecule therapeutic substances, novel plant growth formulations, regulatory compliance, aseptic processing for heat-sensitive materials, delivery technologies/products, safety and risk analyses. Examples include:

• Development and Implementation of scale up of a fermentation facility involving total buildout, specifying equipment, utilities, structural needs, and piping.
• Guidance in planning and developing a novel biotechnology process to produce proteins using a proprietary host by applying chemical engineering principles to a new area.
• Organizational guidance and planning to help launch a business based on imaging technology and proprietary software for a $1 billion life sciences market.
• Technological/Economic Modeling of businesses to recommend strategic alliances/negotiation tactics
• Turnaround program for a small environmental/software applications company
• Devising plan to manufacture biosynthetic chemicals for entry into a lucrative phytochemical business
• Identifying partners for an aseptic processing method that avoids damage to heat-sensitive substances.

ESCAgenetics Corp., San Carlos, CA
Vice President, Director of Research (1987-1994)
Directed $5 million R & D plant biotechnology program to develop marketable products, trade secrets and secure patents. Led programs in plant-based pharmaceuticals and ingredients (e.g., vanilla) derived from plants/plant cells.

Secured an $800,000 National Cancer Institute grant, developed bioreactor/process technology, and devised/implemented a strategy to obtain intellectual property protection for the anti-cancer drug, Taxol.

Secured collaborations for plant-sourced drugs of $500 million potential.

Established a competitive intelligence system. Guided development of plant genetics, immunochemical detection methods, and flavor improvement for beverages.

Guided securing intellectual property in key cases of a unique flavor system and an anti-cancer therapeutic where challenges from government and industry were successfully overcome.

Bayer Corporation(Miles, Inc.), Elkhart, IN
Vice President of Research and Development (1982-1987)
Directed a $12 million R&D program for a $250 million biotechnology division of a large multinational conglomerate; established track record in developing new business programs leading to trade secrets, patents, increased sales, cost containment, and profitable products for health, industrial, and consumer markets.

Led development of an FDA-approved immobilized cell bioreactor process, profitable $200million joint venture facility, start-up of domestic and ex-US bioprocessing plants, and problem solving to secure supply contracts. Led development of analytical methods critical to success of this program.

Secured qualification of $50 million/yr business at a major consumer/health care company and led development of probiotics for health care applications.

Coached a team to stabilize a cell line to produce a protein for sale to a $billion therapeutic market. Led a team that received a corporate award for developing enzymes for a world market.

Transformed a pilot plant operation into a high quality engineering research team. Shortened development time by 1/3 for $50 million products. Solved an impurity problem in a liquid extraction process for a $200 million/yr product.